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  The International Symposium on Chromaffin Cell Biology 2015

 August 17-21, 2015

CONFERENCE PROGRAM
 Monday, August 17, 2015
 9:00 AM -  Exhibition Bump-in
 Urchins
  
 
 
 
 
 10:00 AM -  Registration OPEN
 Urchins
 
 1:00 PM - 1:10 PM Conference Opening: Guest of Honor
 Michaelmas Cay Room
 Chair: Fred Meunier, Damien Keating
 
 1:10 PM - 1:40 PM A day on the Reef
 Michaelmas Cay Room
 Chair: Fred Meunier, Damien Keating
1:10 PM Sex and Violence, Seeing, Signals and Stomatopods: A day on the Reef
 Marshall, J
 Sensory Neurobiology Group, Queensland Brain Institute, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia
 
 
 1:40 PM - 2:25 PM Plenary 1: Reinhard Jahn
 Michaelmas Cay Room
 Chair: Fred Meunier, Damien Keating
1:40 PM TBA
 Jahn, R
 Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Goettingen, Am Fassberg 11, Goettingen, Niedersachsen 37077, Germany
 
 
 2:25 PM - 3:25 PM Exhibition, Tea and Posters
 Urchins
 
 3:25 PM - 5:20 PM Session 2: Lipids in a chromaffin granule's journey: from biosynthesis to fusion
 Michaelmas Cay Room
 Chair: Nicolas Vitale, Christina Mitchell
3:25 PM Chromogranin A / Phosphatidic Acid interaction is crucial to the biogenesis of secretory granules
 Montero-Hadjadje, M1, Carmon, O1, Delestre-Delacour, C1, Tahouly, T2, Fouillen, L3, Bernard, S4, Alexandre, S5, Vitale, N2 and Anouar, Y1
 1- Inserm U982, University of Rouen, Mont-Saint-Aignan, France; 2- CNRS UPR 3212, INCI, Strasbourg, France; 3- CNRS UMR 5200, Metabolome Platform, Bordeaux, France; 4- PRIMACEN, Mont-Saint-Aignan, France; 5- CNRS UMR 6270, PBS, Mont-Saint-Aignan, France.
 
3:50 PM Resident CAPS (aka CADPS) on dense-core vesicles docks and primes vesicles for fusion
 Martin, TF J, Kabachinski, G, Kielar-Grevstad, D, Zhang, X and James, DJ
 Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
 
4:15 PM Involvement of different phospholipase D1 generated phosphatidic acid species during regulated exocytosis
 Ammar, MR, Kassas, N, Costé de Bagneaux, P and Vitale, NN
 INCI, CNRS UPR-3212, 5 rue Blaise Pascal, Strasbourg, Strasbourg 67084, France
 
4:40 PM Uncovering a role for saturated free fatty acids in neuroexocytosis and memory
 Narayana, VK1,2, Windels, F1,2, Sullivan, RK.P1,2, Vitale, N3, Sah, P1,2, Kvaskoff, D2,4 and Meunier, FA1,2
 1. Clem Jones Centre for Ageing Dementia Research, 2. Queensland Brain Institute, Brisbane, 3. Institut des Neurosciences Cellulaires et Intégratives (INCI), UPR-3212 Centre National de la Recherche Scientifique and Université de Strasbourg. 4. University of Queensland Centre for Clinical Research, The University of Queensland, Australia.
 
5:05 PM The Ca2+ sensor Doc2B controls Munc13-1 during GqPCR-mediated potentiation of exocytosis
 Bauer, CS1, Woolley, RJ1 and Seward, EP1
 Biomedical Science, University of Sheffield, Western Bank, Sheffield, S Yorkshire S10 2TN, UK
 
 
 5:25 PM - 6:10 PM Plenary 2: Peter Dunkley
 Michaelmas Cay Room
 Chair: Phillip Robinson
5:25 PM Control of Tyrosine Hydroxylase Activity: Responses to inflammation stress over time
 Dunkley, PR1, Ong, L1, Sominsky, L2, Hodgson, D2 and Dickson, P1
 1School of Biomedical Sciences and Pharmacy, 2School of Psychology. The University of Newcastle, University Drive, Callaghan, Newcastle, NSW 2308, Australia
 
 
 
 6:10 PM - 7:40 PM Posters 1: Welcome Reception, Trade and Posters
 Urchins
 Chromogranin A and its peptide Catestatin play crucial roles in skeletal muscle function in endurance exercise and muscle fiber type-specific glucose metabolism
 Mahata, SK1, Pasqua, T2, Biswas, A2, Sen, S3, Choudhury, BP2 and Bandyopadhyay, G2
 1Medicine, VA San Diego Healthcare System & 2University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0732, USA
 
 10 The anti-hypertensive peptide Catestatin Improves hepatic insulin sensitivity by alleviating endoplasmic reticulum stress and improving mitochondrial function
 Mahata, S1, Mahata, SK2, Avolio, E3, Pasqua, T3, Biswas, N3, Biswas, A3 and Bandyopadhyay, GK3
 California Institute of Technology, 1200 East California Blvd, Pasadena, CA 91125, USA; 2VA San Diego Healthcare System, San Diego, California, USA; 3Department of Medicine, University of California, San Diego, La Jolla, California, USA
 
 11 Chromogranin A deficiency decreases secretory vesicle core formation, catecholamine storage, and energy metabolism in the adrenal medulla
 Mahata, S1, Pasqua, T2, Bandyopadhyay, GK2, Biswas, A2, Perkins, GA3, Sinha-Hikim, AP4, Eiden, L5 and Mahata, SK6
 California Institute of Technology, 1200 East California Blvd, Pasadena, CA 91125, USA; 2Department of Medicine, University of California, San Diego, La Jolla, California, USA; 3National Center for Microscopy and Imaging Research, San Diego, La Jolla, California, USA; 4Charles Drew University of Medicine and Science, Los Angeles, USA; 5Section on Molecular Neuroscience, NIMH-IRP, Bethesda, Maryland, USA; 6VA San Diego Healthcare System, San Diego, California, USA
 
 12 A new calcium independent releasable pool in mouse chromaffin cells
 Moya-Diaz, J1 and Marengo, FD.1
 1. IFIByNE (CONICET). Departamento de Fisiología, Biología Molecular y Celular. Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Pabellon II. Ciudad Universitaria, Buenos Aires, Buenos Aires 1428, Argentina.
 
 14 Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release.
 Jackson, J1, Papadopulos, A2, Meunier, FA2, McCluskey, A3, Robinson, PJ4 and Keating, DJ1
 1Discipline of Human Physiology, Centre for Neuroscience, Flinders University, Adelaide, Australia; 2Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia; 3Centre for Chemical Biology and Chemistry, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, New South Wales, Australia; 4Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia
 
 15 Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in Type 2 diabetic KK-Ay mice
 Zhao, P, Yang, X, Yang, J and Ye, Y
 182 Min-Zu Road, Wuhan, China, Wuhan, HuBei 430074, China
 
 16 Imaging Mass Spectrometry Reveals the Chemistry in Chemically Fixed Adrenal Cells Prepared for Transmission Electron Microscopy Analysis
 Lovric, J1,2, Malmberg, P1,2, Johansson, BR3, Höög, J4, Fletcher, JS1,2 and Ewing, AG1,2,5
 1. Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivagen 10, Gothenburg,412 96, Sweden; 2.National Center for Imaging Mass Spectrometry, Chalmers University of Technology and Gothenburg University, SE-412 96, Gothenburg, Sweden 3.Electron Microscopy Unit, Institute of Biomedicine, University of Gothenburg, SE-405 30, Gothenburg, Sweden; 4.Department of Internal Medicine, Institute of Medicine, University of Gothenburg, SE-413 45, Gothenburg, Sweden; 5.Department of Chemistry and Molecular Biology, University of Gothenburg, SE-405 30, Gothenburg, Sweden
 
 20 Cellular and Molecular mechanisms of hypersecretion in pheochromocytomas
 Croisé, P1, Houy, S1, Lanoix, J2, Calco, V1, Brunaud, L3, Paramithiotis, E2, Chelsky, D2, Tryoen-Toth, P1, Ory, S1 and Gasman, S1
 1-CNRS UPR 3212-INCI, 5 rue Blaise Pascal, Strasbourg, 67084, France; 2-Caprion Proteome, Inc, Montreal, Canada; 3-Hospital Nancy-Brabois (CHU), Nancy, France
 
 21 Characterizing enterochromaffin cell nutrient sensing capabilities in mouse colon and duodenum
 Martin, AM1,2, Lumsden, A1,2 and Keating, DJ1,2
 1. Centre for Neuroscience & Department of Human Physiology, Flinders University, Adelaide, Australia; 2. Nutrition and Metabolism Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia
 
 22 The effects of single and recurrent insulin induced hypoglycaemia on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland
 Senthilkumaran, M1, Johnson, ME1 and Bobrovskaya, L1
 School of Pharmacy and Medical Sciences, University of South Australia, Frome road, Adelaide, South Australia 5000, Australia
 
 23 PKA, AMPK, PGC-1alpha and NRF-1 couple cAMP-dependent antioxidant response and mitochondriogenesis during neuroendocrine differentiation
 Lihrmann, I1, Abid, H1, Cartier, D1, Hamieh, A1, Bellan, A2, Bucharles, C1, Manecka, D1, LePrince, J1, Adriouch, S3 and Anouar, Y1
 1- U982 Inserm - IRIB -Faculty of Sciences, University of Rouen, 76821 Mont-Saint-Aignan, France; 2 - CNRS UMR 7286, CRN2M, Aix-Marseille, France; 3- U905 Inserm - IRIB - Faculty of Medicine, University of Rouen, 76000 Rouen, France
 
 24 Tight mitochondrial control of calcium and exocytotic signals in chromaffin cells at embryonic life
 Padín, JJF1,2, Vestring, SS1,2,4, Fernández-Morales, JJC1,2, Méndez-López, II1,2, Castro-Musial, DD1,2,5, G. de Diego, AAM1,2 and G. García, AA1,2,3
 1) Instituto Teófilo Hernando; 2) Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, Spain. 3) Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, UAM, Madrid, Spain. 4) Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden,Germany. 5) Department of Pharmacology, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.
 
 26 Depressed excitability and ion currents linked to slow exocytotic fusion pore in chromaffin cells of the SOD1G93A mouse model of amyotrophic lateral sclerosis
  Arranz-Tagarro, J1,2, Calvo-Gallardo, E1,2, de Pascual, R1,2, Fernández-Morales, J1, Maroto, M1, Nanclares, C1,2, Gandía, L1,2, de Diego, AM. G.1, Padín, J1,2 and García, AG. 1,2,3,4
 1Instituto Fundación Teófilo Hernando, 2Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain; 3Servicio de Farmacología Clínica, 4Instituto de Investigación Sanitaria, Hospital Universitario de La Princesa, Madrid, Spain
 
 25 Two models for in vivo study of exocytosis by intracellular intravital microscopy
 Masedunskas, A1, Appaduray, M2, Lucas, C2, Kee, A2, Gunning, P1 and Hardeman, E2
 1 Oncology Research Unit & 2 Neuromuscular and Regenerative Medicine Unit, School of Medical Sciences, UNSW, Sydney, Australia
 
 27 The Chromogranin A-derived pyroglutaminated serpinin induces negative inotropism in teleost and amphibian hearts
 Tota, B1, Imbrogno, S1, Mazza, R1, Pugliese, C1, Filice, M1, Angelone, T1, Loh, PY2 and Cerra, MC1
 1 Dept. of Cell Biology, University of Calabria, Ponte Bucci , Arcavacata di Rende, Cosenza, Italy 87030, Italy; 2 Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md 20892, USA
 
  Biogenesis of large dense core vesicles in adrenal chromaffin cells of newborn mice
 Dembla, E, Krause, E, Rettig, J and Becherer, U
 Kirrbergerstrasse, Bldg. 48, Homburg/Saar, Saarland 66421, Germany
 
 
 Monday, August 17, 2015
 7:40 PM -  Dinner at Leisure
 see website for suggested restaurants
 
 Tuesday, August 18, 2015
 8:20 AM - 8:30 AM Housekeeping
 Michaelmas Cay Room
 Chair: Damien Keating
 
 8:30 AM - 10:25 AM Session 4: Exo-endocytosis coupling in neurons and neuroendocrine cells
 Michaelmas Cay Room
 Chair: Stephane Gasman
8:30 AM 28 Spatiotemporal control of ex-endocytic membrane traffic
 Haucke, V
 Molecular Pharmacology and Cell Biology, Leibniz Institute for Molecular Pharmacology, Robert-Roessle-Str. 10, Berlin, D-13125, Germany
 
8:55 AM 29 Membrane lipid reorganization and Rho GTPases signaling regulate exo-endocytosis coupling of large dense core vesicles in chromaffin cells
 Houy, S, Estay-Ahumada, C, Croisé, P, Calco, V, Haeberlé, A, Bailly, Y, Chasserot-Golaz, S, Bader, M, Ory, S and Gasman, S
 CNRS UPR 3212-INCI, 5 rue Blaise Pascal, Strasbourg, 67084, France
 
9:20 AM 30 Imaging vesicle exo- and endocytosis in chromaffin cells
 Wu, L
 NINDS, NIH, 35 Convent Dr., Bethesda, MD 20892, USA
 
9:45 AM 31 Dynamin Rings, Regulation and Allostery: Sensing the oligomerisation signal
 Robinson, PJF, Collett, M, Krishnan, S and McCluskey, A
 Cell Signalling Unit, Children's Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia
 
10:10 AM 32 Rapid recovery of exocytosis after action potential-like stimulation in mouse chromaffin cells is coupled to a fast endocytotic process
 Moya Díaz, J, Álvarez, YD., Montenegro, M, Belingheri, V and Marengo, FD.
 IFIByNE (CONICET). Departamento de Fisiología,Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales - Universidad de Buenos Aires, Ciudad Universitaria. Pabellón 2. 2do piso, Buenos Aires, CABA 1428, Argentina.
 
 
 10:25 AM - 11:00 AM Coffee, Posters and Exhibition
 Urchins
 
 11:00 AM - 1:05 PM Session 5: Cell signalling in other cell types: What can we learn?
 Michaelmas Cay Room
 Chair: Damien Keating
11:00 AM 33 How the exocytotic fusion pore opens and closes?
 Jorgačevski, J1,2, Vardjan, N1,2, Calejo, AC.2, Guček, A2, Rituper, B2, Kreft, M1,2,3 and Zorec, R1,2
 1) Celica Biomedical, Tehnološki Park, Ljubljana, Slovenia EU; 2) LN-MCP, Institute of Pathophysiology, Univerza v Ljubljani, Medicinska fakulteta, Zaloška cesta 4, Ljubljana, Slovenia EU; 3) Biotechnical Faculty, Univerza v Ljubljani, Ljubljana, Slovenia EU
 
11:25 AM 34 Mechanisms controlling insulin granule exocytosis in health and disease
 Thorn, P
 School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia
 
11:50 AM 35 Enterochromaffin cells display distinct release kinetics
 Keating, DJ
 Human Physiology and Centre for Neuroscience, Flinders University, PO Box 2100, Adelaide, SA 5001, Australia
 
12:15 PM 36 The other synapse: calcium-dependent exocytosis in the immune system
 Rettig, J
 Department of Physiology, Saarland University, Kirrberger Strasse, Homburg, 66421, Germany
 
12:40 PM 37 Calpains cleave dysferlin to release a synaptotagmin-like module for the calcium-dependent exocytosis of membrane repair
 Redpath, GMI1,2, Woolger, N1,2, Lek, A1,2, Piper, A1,2, Lemckert, FA1,2, Greer, PA4, North, KN3 and Cooper, ST1,2
 1. Institute for Neuroscience and Muscle Research, The Children's Hospital at Westmead, The University of Sydney, Locked Bag 4001, Westmead, Sydney, NSW 2145, Australia; 2. Discipline of Paediatrics and Child Health, The University of Sydney, NSW 2006, Australia. ; 3. Murdoch Children’s Research Institute, The Royal Children's Hospital, Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences. University of Melbourne, VIC 3010, Australia; 4. Department of Pathology and Molecular Medicine, Queen's University, Division of Cancer Biology and Genetics, Queen's Cancer Research Institute, Kingston, Ontario K7L 3N6, Canada
 
 
 1:05 PM - 2:05 PM Lunch, Posters and Exhibition
 Urchins
 
 2:05 PM - 3:25 PM Session 6: Chromogranin/secretogranin peptides
 Michaelmas Cay Room
 Chair: Bruno Tota
2:05 PM 38 Cardiac interaction and signalling between full length Chromogranin A and Tumor Necrosis Factor alpha
 Tota, B1, Pasqua, T1, Corti, A2, Cerra, M1 and Angelone, T1
 1 Dept of Biology, Ecology, and E.S., University of Calabria, Rende (CS), Italy; 2 Tumor Biology and Vascular Targeting Unit, Division of Molecular Oncology, San Raffaele Scientific Institute, Milan, Italy.
 
2:30 PM 39 Human genetic variants of the chromogranin A-derived dysglycemic peptide Pancreastatin: implications for cardiometabolic disorders
 Mahapatra, NR
 Department of Biotechnology, Indian Institute of Technology Madras, Alumni Avenue, Chennai, Tamil Nadu 600036, India
 
2:55 PM 40 Secretoneurin gene therapy
 Kirchmair, R
 Internal Medicine III, Medical University Innsbruck, Anichstr. 35, Innsbruck, Tyrol 6020, Austria
 
3:20 PM  Open discussion
 
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 3:25 PM - 4:05 PM Tea, Posters and Exhibition
 Urchins
 
 4:05 PM - 6:00 PM Session 7: Cytoskeletal mechanisms linked to chromaffin cell function
 Michaelmas Cay Room
 Chair: Luis Guttierrez
4:05 PM 41 Measurement and cytoskeletal regulation of open and closed exocytosis
 Ewing, AG
 Chemistry and Chemical Engineering, Chalmers University, Kemivagen 10, Gothenburg, VG 41296, Sweden
 
4:30 PM 42 An Acto-Myosin II Constricting Ring Initiates the Fission of Activity-Dependent Bulk Endosomes in Neurosecretory Cells
 Gormal, RS, Nguyen, TH, Martin, S, Papadopulos, A and Meunier, FA
 Queensland Brain Institute, The University of Queensland, Upland road, St Lucia, Brisbane, QLD 4072, Australia
 
4:55 PM 43 F-actin organization and the fate of vesicles and organelles.
 Villanueva, J, Gimenez-Molina, Y, Viniegra, S and Gutiérrez, LM.
 Instituto de Neurociencias de Alicante, CSIC-Universidad Miguel Hernandez, Cra de Valencia s/n, Sant Joan delacant, Alicante, Alicante 03550, Spain
 
5:20 PM 44 Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking
 Papadopulos, A1, Gomez, GA2, Martin, S1, Jackson, J3, Gormal, RS1, Keating, DJ3, Yap, AS2 and Meunier, FA1
 1 The Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University Of Queensland, Building 79, Upland Rd, St Lucia, St Lucia, QLD 4072, Australia; 2 Division of Molecular Cell Biology Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. 3 Molecular and Cellular Neuroscience Laboratory, Department of Human Physiology, Flinders University, Adelaide, South Australia, Australia
 
5:45 PM 45 Annexin A2 bundles actin filaments to promote secretory granule docking and fusion
 Gabel, M1, Delavoie, F2, Royer, C3, Demais, V3, Bailly, Y1, Vitale, N1, Bader, M1 and Chasserot-Golaz, S1
 1- INCI UPR 3212 CNRS, 5 Rue Blaise Pascal, Strasbourg, FRANCE 67084; 2- UMR5099 CNRS-Université de Toulouse III, 118 route de Narbonne, Toulouse, France 31000; 3-Plateforme Imagerie In Vitro, Neuropôle de Strasbourg 5 Rue Blaise Pascal, Strasbourg, France 67084
 
 
 6:00 PM - 7:45 PM Dinner at Leisure
 see website for suggested restaurants
 
 8:00 PM - 10:30 PM Session 8: Wine and Cheese - Posters and Exhibition
 
 
 8:00 PM - 9:00 PM Session 8: Neurotransmitter release
 MIchaelmas Cay Room
 Chair: John Rostas
8:00 PM 46 Huntingtin-associated protein 1 (HAP1) is a Synapsin-binding protein and regulates vesicle exocytosis and endocytosis
 Mackenzie, KD, Lumsden, AL, Guo, F, Duffield, MD, Chataway, TK, Zhou, X and Keating, DJ
 Human Physiology, Flinders University, Sturt Road, Bedford Park, Adelaide, SA 5042, Australia
 
8:10 PM 47 Unconventional Research demands flexible tools
 Swinscoe, T and Merrington, S
 Leica Microsystems
 
8:15 PM 48 Does depolarization-induced reprogramming of the presynaptic phosphoproteome mediate changes in neurotransmitter release?
 Engholm-Keller, K1, 2, Robinson, PJ.1 and Graham, M1
 1 Children's Medical Research Institute, Westmead, NSW, Australia; 2 Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
 
8:25 PM 49 Effect of external high osmolality on vesicular neurotransmitter content in chromaffin cells
 Fathali, H, Majdi, S, Lovric, J, Cans, A and Ewing, A
 Chemistry and Chemical Engineering, Chalmers Tekniska Högskola AB, Maskingränd 2, Gothenburg , Sweden 41296, Sweden
 
8:35 PM 50 The Effect of Excited Fluorophore on Vesicle Fusion at the Surface of the Electrode
 Najafinobar, N1, Lovric, J1, Dunevall, J1, Fathali, H1, Ewing, A1,2 and Cans, A1
 1Department of Chemical and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41296 Gothenburg, Sweden; 2 Department of Chemistry and Molecular Biology, University of Gothenburg, 412 96 Gothenburg, Sweden
 
8:45 PM 51 Dissecting phosphoregulation of exocytosis: assessing the roles of kinases in late steps of the exocytotic pathway
 Abbineni, P, Dabral, D and Coorssen, J
 Department of Molecular Physiology, and Molecular Medicine Research Group, School of Medicine, University of Western Sydney, Building 30, Goldsmith Avenue, Campbelltown, Sydney, NSW 2560, Australia
 
 
 8:00 PM - 9:00 PM Session 8: Neurotransmitter in diseases
 Urchins
 Chair: Reinhard Jahn
8:00 PM 52 Augmented catecholamine release from chromaffin cells of diabetic and hypertensive rats
 Méndez-López, II.1, 2, Arranz-Tagarro, JJ. A.1, 2, Padín, JJ.F1, 2, Musial, DD.4, Bomfim, GG.4, Miranda-Ferreira, RR.4, Jurkiewicz, AA.4, Jurkiewicz, NN.4 and García García, AA.1, 2, 3
 1- Instituto Teófilo Hernando de I+D del Medicamento, Madrid, Spain; 2- Dep. de Farmacología y Terapéutica, Fac. Medicina, Universidad Autónoma de Madrid. Madrid, Spain; 3- Instituto de Investigación Sanitaria, Servicio de Farmacología Clínica, Hospital Universitario de La Princesa, Madrid, Spain; 4- Dep. Farmacología, Universidade Federal de São Paulo, São Paulo, Brazil
 
8:20 PM 55 Sorting Nexin 27 links PTHR Signalling to the Retromer for Postnatal Bone Growth
 Chan, A1, Clairfeuille, T2, Landao, E1, Kinna, G2, Ng, P1, Loo, L3, Teasdale, RD2, Hong, W3, Collins, BM2 and Pavlos, NJ1
 1. School of Surgery,The University of Western Australia, Crawley, Western Australia 6009; 2. Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072; 3. Institute of Molecular and Cell Biology, A*STAR, Proteos Building, Singapore 138673
 
8:30 PM 54 An in vivo examination of IL-6 actions in the mouse adrenal gland
 Tranter, DE and Bunn, SJ
 Department of Anatomy, University of Otago, Dunedin, Otago, New Zealand
 
8:40 PM 56 Unconventional Research demands flexible tools
 Swinscoe, T and Merrington, S
 Leica Microsystems Pty Ltd, Unit 3, 112 -118 Talavera Road, North Ryde, Sydney, NSW 2113, Australia
 
8:45 PM 57 Why (some) old men get hypertension: testosterone and a receptor tyrosine kinase EphB6 in concert regulate catecholamine synthesis and release in chromaffin cells, hence modulating blood pressure
 Wang, Y1, Ledoux, J2, Luo, H1 and Wu, J1
 1CHUM Research Center and 2Montreal Heart Institute, University of Montreal
 
8:55 PM 58 Persistently active Rab3a, and a chimaeric protein containing its amino-terminal portion, prevent the late stages of sperm exocytosis by stabilizing open fusion pores
 Bustos, MA1, Quevedo, MF1, Roggero, CM2, Lucchesi, O1, Mayorga, LS1 and Tomes, CN1
 Morpho physiology, IHEM-CONICET, Cuyo National University, Centro Universitario , Mendoza, Mendoza 5500, Argentina
 
 
 Wednesday, August 19, 2015
 8:20 AM - 8:30 AM Housekeeping
 Michaelmas Cay Room
 Chair: Fred Meunier
 
 8:30 AM - 10:25 AM Session 9: Biophysics
 Michaelmas Cay Room
8:30 AM 59 Fusion pore opening
 Lindau, M1,2, Zhao, Y2, Fang, Q2, Sharma, S2 and Rathore, S1
 1 School of Applied and Engineering Physics, Cornell University, 272 Clark Hall, Ithaca, NY 14850, United States; 2 Laboratory for Nanoscale Cell Biology, Max-Planck-Institute for Biophysical Chemistry, D-37077 Goettingen, Germany
 
8:55 AM 60 TBA
 Coorssen, J
 Molecular Physiology, School of Medicine, University of Western Sydney, Locked Bag 1797, Penrith, NSW 1797, AUSTRALIA
 
9:20 AM 61 Modeling Mechanisms Shaping Endoplasmic Reticulum
 Shemesh, T2, Rapoport, TA3 and Kozlov, MM1
 1Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel, 69978, Israel; 2Technicon, Biology, Haifa, Israel; Biology, Haifa, Israel, 3Harvard University, Medical School, Boston, MA, USA
 
9:45 AM 62 Pituitary Adenylate Cyclase-Activating Peptide (PACAP) excitation of the adrenal medulla.
 Smith, C1
 Physiology and Biophysics, Case Western Reserve University, 2109 Adelbert Road, SOM Rm E521, Cleveland, OH 44106, USA
 
10:10 AM 63 Multiple mechanisms for vesicle content release in the post-fusion phase of surfactant exocytosis
 Miklavc, P, Frick, M, Ehinger, K, Dietl, P, Kittelberger, N and Breunig, M
 Institute of General Physiology, Ulm University, Albert-Einstein-Allee 11, Ulm, Baden-Wuerttemberg 89081, Germany
 
 
 10:25 AM - 11:00 AM Coffee, Posters and Exhibition
 Urchins
 
 11:00 AM - 12:40 PM Session 10: Dan O'Connor Memorial Session
 Michaelmas Cay Room
11:00 AM 64 Cell-specific function of chromogranin A in dense core vesicle biogenesis and core formation in adrenomedullary chromaffin and pancreatic beta cells
 Mahata, SK1, Mahata, S3, Pasqua, T2, Biswas, A2, Perkins, GA4, Sinha-Hikim, AP5 and Eiden, L6
 Medicine, VA San Diego Healthcare System & University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0732, USA
 
11:20 AM 65 Coupling of oxidative stress control and energy supply during PC12 cell differentiation
 Anouar, Y1, Abid, H1, Cartier, D1, Hamieh, A1, François-Bellan, A2, Bucharles, C1, Manecka, D1, Leprince, J1, Adriouch, S3 and Lihrmann, I1
 1, Inserm, U982, Institute for Research and Innovation in Biomedicine, University of Rouen, Normandy University, Mont-Saint-Aignan, France; 2, CNRS UMR 7286, CRN2M, Aix-Marseille University, Marseille, France ; 3, Inserm U905, Institute for Research and Innovation in Biomedicine, Rouen, France
 
11:40 AM 66 Interleukin-6 interaction with the chromaffin cell
 Bunn, SJ1
 Centre for Neuroendocrinology and Dept of Anatomy, University of Otago, PO Box 913, Dunedin, Otago 9001, New Zealand
 
12:10 PM 67 PACAP at the adrenomedullary synapse, and in the brain: a master regulator of the stress response
 Eiden, LE
 SMN, LCMR, NIMH-IRP, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
 
12:20 PM 68 ATP in secretory vesicles, Why?
 Estevez-Herrera, J1, Machado, j1, Pardo, MR1,2, Santana, AG1, Dominguez, N1,3 and Borges, R1,2
 1-Pharmacology, University of La Laguna, Facultad de Medicina, La Laguna, Tenerife E38071, Spain; 2-IUBO, University of La Laguna, La Laguna, Tenerife E38071, Spain.; 3- Present address: Center for Neurogenomics and Cognitive Research (CNCR) Amsterdam. The Neerderlands.
 
 
 12:40 PM - 12:50 PM GROUP PHOTO
 Arlington Bar Steps
 
 12:50 PM - 1:50 PM Lunch with Posters and Exhibition
 Urchins
 
 1:50 PM - 3:10 PM Session 11: Young Investigators
 Michaelmas Cay Room
 Chair: Phil Dickson
1:40 PM 69 First identification of a human mutation in synaptotagmin1 reveals perturbation of synaptic vesicle cycling
 Gordon, SL1, 3, Baker, K2, Cousin, MA1 and Raymond, L2
 1. Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK; 2. Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK; 3. Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, Melbourne, Vic 3052, Australia
 
2:00 PM 70 Phosphoproteomic profiling of activity-dependent presynaptic signalling
 Engholm-Keller, K, Robinson, PJ and Graham, ME
 Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Australia
 
2:20 PM 71 Munc13s in LDCV docking and priming
 Man, KM1, Imig, C1, Walter, AM2, Pinheiro, PS3, Stevens, DR4, Rettig, J4, Sørensen, JB3, Cooper, BH1, Brose, N1 and Wojcik, SM1
 1 Molecular Neurobiology, Max Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, D-37075 Goettingen, Germany; 2 Leibniz Institute for Molecular Pharmacology, D-13125 Berlin, Germany; 3 Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences and Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, 2200N Copenhagen, Denmark; 4 Department of Physiology, Saarland University, D-66421 Homburg, Saar, Germany
 
2:40 PM 72 Molecular mechanism of LDCV dead-end docking in mouse chromaffin cells
 Dembla, E1, Bruns, D2, Rettig, J1 and Becherer, U1
 1.Department of Physiology, Cellular Neurophysiology, Saarland University, Building 59, Homburg, Saar 66421, Germany; 2.Department of Physiology, Molecular Neurophysiology, Saarland University, Building 59, Homburg, Saar 66421, Germany
 
3:00 PM 73 Flexibility of v-SNARE transmembrane domain regulates vesicular exocytosis
 Dhara, M1, Yarzagaray, A1, Schwarz, Y1, Mohrmann, R1 and Bruns, D1
 1. Department of Physiology, University of Saarland, Kirrberger Str. 8, Building No. 59, Homburg, Saarland 66421, Germany
 
 
 3:10 PM - 3:45 PM Tea Posters and Exhibition
 Urchins
 
 3:45 PM - 4:25 PM Plenary 3: Hans-Herman Gerdes Memorial Lecture
 Michaelmas Cay Room
 Chair: Damien Keating
3:45 PM 74 Gerdes-Memorial: A Sympathetic Drive of Locomotion
 Rudolf, R1,2,3
 1 Interdisciplinary Center for Neurosciences, University of Heidelberg, Germany; 2 Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Germany; 2 Institute of Toxicology and Genetic, Karlsruhe Institute of Technology, Germany
 
 
 4:25 PM - 4:35 PM BioBreak
 
 
 4:35 PM - 6:10 PM Session 13: Chromogranin / secretogranin proteins in health & diseases
 Michaelmas Cay Room
 Chair: Sushil Mahata , Angelo Corti
4:35 PM 75 Regulation of tumor growth by circulating chromogranin A
 Curnis, F1, Bianco, M1, Gasparri, A1, Dallatomasina, A1, Colombo, B1, Sacchi, A1, Fiocchi, M1, Borges, R2, Mahata, SK3 and Corti, A1
 1) Tumor Biology and Vascular Targeting Unit, Division of Experimental Oncology, San Raffaele Scientific Institute, Milan; 2) Pharmacology Unit, Medical School, La Laguna University, Tenerife, Spain; 3) VA San Diego Healthcare System and University of California, San Diego, USA
 
4:55 PM 76 Novel roles for Chromogranin A peptide catestatin in cardiac metabolism and physiology
 Senapati, S1, Schilling, JM2,3, Pasqua, T2, Biswas, N2, Avolio, E2, Bandyopadhyay, G2, Roth, DM2,3, Webster, NJG2,3, Patel, HH2,3 and Mahata, SK2,3
 Please Include the Full list of Authors, as follows: Sanjib Senapati,1 Jan M. Schilling,2,3 Teresa Pasqua,2 Venkat R. Chirasani,1 Nilima Biswas,2 Ennio Avolio,2 Hongqiang Cheng,4 Suvajit Sen,5 Alice E. Zemljic-Harpf,2,3, John P. Headrick,6 Heidi N. Fridolfsson,2,3 Adam Kassan,2,3 Kevin Yei,7 Sumana Mahata,7 Gautam Bandyopadhyay,2 David M. Roth,2,3 Nicholas J.G. Webster,2,3 Hemal H. Patel,2,3,* and Sushil K. Mahata.2,3,* 1Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India, 2University of California, San Diego, La Jolla, CA, USA, 3VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA, USA, 4Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China, 5David Geffen School of Medicine, University of California, Los Angeles, 6Heart Foundation Research Centre, Griffith Health Institute, Australia, 7California Institute of Technology, Pasadena, CA.
 
5:15 PM 77 Localization and function of serpinins
 Loh, P
 NIH, 49, Convent Drive, Bldg 49, Rm 6C10, Bethesda, MD 20892, USA
 
5:35 PM 78 Combined measurement of granin and granin-derived peptides improves the diagnosis of pheochromocytoma
 Yon, L1,2,3, Guillemot, J1,2,3,4, Guérin, M1,2,3, Montéro-Hadjadje, M1,2,3, Leprince, J1,2,3, Lefebvre, H1,2,3,5, Klein, M6, Muresan, M7 and Anouar, Y1,2,3
 1 INSERM Unit 982, Mont-Saint-Aignan, France; 2 Normandie University, France; 3 Rouen University, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Mont-Saint-Aignan, France; 4 Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada; 5 Department of Endocrinology, Diabetes and Metabolic Diseases, Rouen University Hospital, Bois-Guillaume, France; 6 Department of Endocrinology, Hôpital de Brabois, University of Nancy, Nancy, France; 7 Unit of Endocrinology, Hôpital Notre-Dame de Bon Secours, Metz, France
 
5:55 PM 79 Chromogranin A deficiency decreases secretory vesicle core formation, catecholamine storage, and energy metabolism in the adrenal medulla
 Mahata, S1, Pasqua, T2, Bandyopadhyay, GK2, Biswas, A2, Perkins, GA3, Sinha-Hikim, AP4, Eiden, L5 and Mahata, SK6,1
 1California Institute of Technology, Pasadena, California, USA; 2Department of Medicine, University of California, San Diego, La Jolla, California, USA; 3National Center for Microscopy and Imaging Research, San Diego, La Jolla, California, USA; 4Charles Drew University of Medicine and Science, Los Angeles, USA; 5Section on Molecular Neuroscience, NIMH-IRP, Bethesda, Maryland, USA; 6VA San Diego Healthcare System, San Diego, California, USA
 
 
 6:10 PM - 6:15 PM BioBreak
 
 
 6:15 PM - 7:15 PM Plenary 4: Erwin Neher
 Michaelmas Cay Room
 Chair: Corey Smith
6:10 PM 80 Catecholamine and Glutamate Release: A Comparison
 Neher, E
 Max Planck Institute for Biophysical Chemistry, Goettingen, Am Fassberg 11, Goettingen, Lower Saxony 37077, Germany
 
 
 7:10 PM - 7:30 PM Pre-dinner drinks
 
 
 7:30 PM - 11:00 PM Conference Dinner
 
 
 Thursday, August 20, 2015
  -  EXCURSION DAY! Great Barrier Reef - Diving, Snorkelling; Daintree Rain forest
 
 
 Friday, August 21, 2015
 8:20 AM - 8:30 AM Housekeeping
 Michaelmas Cay Room
 Chair: Damien Keating
 
 8:30 AM - 10:35 AM Session 15: Mechanisms of SNARE-mediated exocytosis
 
 Chair: Brett Collins
8:30 AM 81 Elucidating the molecular mechanisms of neurotransmitter release and its regulation
 Rizo, J
 Biophysics, UT Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
 
8:55 AM 82 Elucidating the role of syntaxin-1 N-peptide in neurotransmitter release in PC12 cells and C. elegans
 Park, S and Sugita, S
 University of Toronto; University Health Network, 60 Leonard Avenue, 7KD-419, Toronto, Toronto, ONTARIO M5T2S8, Canada
 
8:55 AM 83 Assembly of the secretory machinery during insulin granule docking
 Barg, S and Gandasi, NR
 Medical Cell Biology, Uppsala University, BMC 571, Uppsala, - 75123, Sweden
 
9:45 AM 84 DOC2B translocates in a diffusion-like and in a PIP2 dependent manner to the plasma membrane
 Michaeli, L, Gottfried, I and Ashery, U
 Department of Neurobiology, Life Sciences Faculty, The Sagol School of Neuroscience, Tel aviv University, Tel Aviv, Israel
 
10:10 AM 85 Structure-function studies of Munc18 in vesicle exocytosis
 Martin, S1, Papadoulos, A1, Chai, Y1, Malintan, N1, Martin, J2, Meunier, F1 and Collins, B2
 1. Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia; 2. Institute for Molecular Bioscience, University of Queensland, Carmody Rd, St Lucia, QLD 4171, Australia
 
 
 11:05 AM - 1:05 PM Session 16: From the pre- to the post-synapse
 Michaelmas Cay Room
 Chair: Rudiger Rudolf
11:05 AM 86 The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones
 Brose, N
 Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, Goettingen, Lower Saxony 37075, Germany
 
11:30 AM 87 Visualization of AMPA Receptor Synaptic Plasticity In Vivo
 Huganir, RL
 The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University , 725 North Wolfe Street, Baltimore, MD 21205, USA
 
11:55 AM 88 Role of Bassoon in the regulation of neurotransmitter release
 Montenegro-Venegas, C1, Pina, E2, Marini, C1, Gundelfinger, E1, Lazarevic, V2 and Fejtová, A2
 1AG Chemical Synapses, Department of Neurochemistry and Molecular Biology and 2RG Presynaptic Plasticity, Leibniz Institute for Neurobiology, Magdeburg, Germany
 
12:120 PM 89 Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 Controls the Specific Retrieval of Synaptotagmin-1
 Gordon, SL1, Zhang, N2, Fritsch, MJ2, Esoof, N2, Campbell, DG2, Macartney, T2, Peggie, M2, van Aalten, DMF2, Alessi , DR2 and Cousin, MA1
 1) Centre for Integrative Physiology, University of Edinburgh, 15 George Square, Edniburgh, Lothian EH10 6QQ, Scotland; 2) Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
 
12:45 PM 90 Neurotransmission alterations related to the progression of Alzheimer´s disease in 3xTg-AD transgenic mice
 Nanclares, CC1, Colmena, II1, Crespo-Castrillo, AA1, Calvo-Gallardo, EE1, Arranz-Tagarro, JJA1, G. García, AA1 and Gandía, LL1
 1 Instituto Teófilo Hernando, Departamento de Farmacologia y Terapeutica, Facultad de Medicina, Universidad Autonoma de Madrid. C/Arzobispo Morcillo, 4, Madrid, 28029, Spain.
 
 
 2:00 PM - 4:00 PM Session 17: Biosensing and Signal processing
 Michaelmas Cay Room
 Chair: Valentina Carrabelli
2:00 PM 91 Detection and estimation of amperometric spike parameters using matched filtering algorithms
 Balaji Ramachandran, S1,2 and Gillis, KD1,2
 1Department of Bioengineering, 2Dalton Cardiovascular Research Center, University of Missouri, Columbia, 134 Research Park Dr, Columbia, MO 65211, USA
 
2:25 PM 92 The function of SNARE membrane anchors
 Jackson, M
 Department of Neuroscience, University of Wisconsin, 1111 Highland Ave, Madison, Madison, Wisconsin 53705, USA
 
2:50 PM 93 TBA
 Xu, T
 Institute of Biophysics, CAS, 15 Datun Road, Chaoyang District, Beijing, Beijing 100101, China
 
3:15 PM 94 TBA
 Bruns, D
 Medical Faculty, CIPMM, Molecular Neurophysiology, University of Saarland, Kirrbergerstr. 100, Homburg, Saarland 66421, Germany
 
3:40 PM 95 Studies of neurosecretion by remote control of exocytosis and endocytosis with light
 Gorostiza, P1,2,3
 !1) Institute for Bioengineering of Catalonia, Baldiri Reixac 15-21, Barcelona, Barcelona 08028, Spain; (2) Catalan Institution for Research and Advanced Studies (ICREA); (3) Networking Center of Biomedical Research in Biomaterials, Bioengineering and Nanomedicine (CIBER-BBN)
 
 
 4:00 PM - 5:35 PM Session 18: Session 18 and Plenary V: Matthijs Verhage
 Michaelmas Cay Room
 Chair: Fred Meunier
4:00 PM 96 Regulation of phosphoinositide signaling
 Mitchell, CA, Dyson, J, Davies, M, Gurung, R and Ooms, L
 1Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Melbourne, Victoria 3800, Australia
 
4:25 PM 97 Regulating synaptic strength across the dendritic tree
 Letellier, M1, Chater, T2, Park, Y2 and Goda, Y2
 1. Université Bordeaux, Institut Interdisciplinaire de Neurosciences, UMR5297, Bordeaux, FRANCE; 2. RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, JAPAN
 
4:50 PM 98 Trafficking, docking and fusion of secretory vesicles
 Verhage, M
 Center for Neurogenomics and Cognitive Research, Vrije Universiteit (VU) and VU Medical Center, Amsterdam, The Netherlands
 
 
 5:35 PM - 5:45 PM Conference Close, Awards and Prizes
 Michaelmas Cay Room