POSTERS 2003 EMT MEETING
21 Novel CD44 splice variants associated with alternative splicing of FGFR-2 and cell phenotype
Choi, JKW, Gibbins, JR, Lyons, JG and Hunter, N
Pathology and IDR, University of Sydney and Westmead Hospital, Sydney, Australia, Department of Pathology, The University of Sydney, Institute of Dental Research, Westmead Millenium Institute, Westmead; Kanematsu Laboratories, Royal Prince Alfred Hospital, Camperdown
22 Prevention of dispersion of the medial epithelial seam but not breakdown of the basal lamina during palatal fusion. The effect of papaverine in organ culture.
Tazawa, YM, Gibbins, JR, Simonian, M , Manthey, A and Hunter, N
Pathology and IDR, University of Sydney and Westmead Hospital, Sydney, Australia, Department of Pathology, The University of Sydney, Institute of Dental Research, Westmead Millenium Institute, Westmead
23 The 67 kDa Laminin Receptor: Investigating its functional role in EMT in Development and Cancer
Lewis, SL, Farlie, PG and Newgreen, DF
Embryology, Murdoch Childrens Research Institute, Melbourne, Australia; Murdoch Childrens Research Institute, Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia, 3052.
24 APC recruits β-catenin, EB1 and DLG to microtubule filaments and membrane protrusions
Leung, Louie and Henderson, BR
Westmead Millennium Institute, University of Sydney, Sydney, Australia
25 Differential regulation of E-Cadherin and its repressors Slug and Snail in the PMC42 model of epithelio-mesenchymal transition (EMT) in human breast carcinoma.
Thompson, E.W.*#, Bills M.M.# , Blick, T.#, Fridman, M#., Arvanitis, A*#., Price, J.T.#, Waltham, M.#, Ackland, L.§, Gilles, C.**, Savagner, P^. and Newgreen, D.F.†
*University of Melbourne Department of Surgery; #St. Vincent’s Institute of Medical Research, Melbourne; §Department of Biochemistry, Deakin University, Melbourne; †Murdoch Children’s Research Institute, Melbourne; **Laboratory of Developmental and Tumor Biology, Université de Liège, Liège, Belgium; ^EMI 0229 INSERM, Montpellier, France
26 Cell-free 59 kDa integrin-linked kinase as a potential biomarker of ovarian cancer
Ahmed N, Oliva K, Riley C, Stutt E, Barker G, Quinn M and Rice G
Gynaecological Cancer Research Centre, Royal Women’s Hospital, Melbourne, Australia
27 Overexpression of Autocrine Motility Factor (AMF) implicates epithelial to mesenchymal transition in human oral squamous carcinoma cells.
Niinaka Y, Haga A, Yamaguchi S, Raz A and Amagasa T
Tokyo Medical and Dental University, Tokyo, Japan; Gifu Pharmaceutical University, Gifu, Japan; Karmanos Cancer Institute, Detroit, MI
28 Transcriptional regulation of Slug expression in neural crest formation.
Sakai, D, Endoh, Y, Osumi, N and Wakamatsu, Y
Department of Developmental Neurobiology, Graduate school of Medicine, Tohoku university, Sendai, Miyagi, Japan
29 Fociemix, a novel basal lamina of stratified epithelia
Rodgers, RJ and Irving-Rodgers, HF
Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia
30 A cortactin/CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton.
Lyons, RJ, Lynch, DK, Winata, S, Hughes, WE, Lehrbach, GM, Wasinger, V, Corthals, G and Cordwell, S and Daly, RJ
Diabetes and Obesity Research Program and Protein Analysis Facility, Garvan Institute of Medical Research, St Vincent’s Hospital, Sydney, NSW 2010, Australia and Australian Proteome Analysis Facility, Macquarie University, Sydney, NSW 2109, Australia.
31 The deubiquitylating enzyme FAM and endocytosis of the cadherin-catenin adhesion complex
Millard, SM and Wood, SA
Child Health Research Institute, Adelaide, Australia School of Molecular & Biomedical Science, The University of Adelaide, Australia Centre for the Molecular Genetics of Development, Adelaide, Australia
32 Serum-dependent AJ formation in NRK cells
Yonemura, S and Miyake, Y
Laboratory for Cellular Morphogenesis, RIKEN Center for Developmental Biology, Kobe, Japan
33 The Wnt/FZD pathway in the regulation of EMT in colonic adenocarcinomas.
Elizabeth Vincan, Phillip K Darcy, Nancy I Reyes, Robert JS Thomas, Mark J Smyth and Wayne A Phillips
Surgical Oncology Laboratory and Cancer Immunology Programme, Research Division, Peter MacCallum Cancer Centre
34 Invasive phenotype of cervical cancer cell line: implication of EMT
Vipra, MR and Chiplonkar, JM
Cell Biology, National Centre For Cell Science, Pune, India.
35 Mouse teratocarcinoma F9 cells as a model to elucidate epithelium formation mechanisms
Nagafuchi, A, Ikenouchi, J, Fukunaga, Y, Shimizu, M, Komiya, S and Yoshinaga, T
Cellular Interactions, IMEG, Kumamoto Univ., Kumamoto, Japan
36 Extracellular factors induce cellular organisation, alter expression of epithelial
markers and modify EMT, in PMC42-LA breast carcinoma cells
Ackland, L, #Waltham, M, *Newgreen, D, ßArvenitis, A, Lebret, S, #Price, J, #Fridman, M and ßThompson, E
Biological and Chemical Sciences, Deakin University, Melbourne, Australia; *The Murdoch Children’s Research Institute, Parkville, Melbourne, 3052, Australia; #St. Vincent’s Institute of Medical Research, Fitzroy, Melbourne, 3065, Australia; ßUniversity of Melbourne, Department of Surgery, St. Vincent’s Hospital, Melbourne, Australia
37 A link between the endocytosis of FGFR and E-cadherin. Implications for co-regulation of cell growth and adhesion.
Bryant, DM and Stow, JL
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia; Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, QLD Australia
38 Cadherin-11 in breast cancer cell invasion and lymphangiogenesis
Feltes, CM, Hampel, C, Blaschuk, O* and Byers, SW
Lombardi Cancer Center, Georgetown University, Washington, USA; Lombardi Cancer Center, Georgetown University, Washington DC and *Department of Surgery, McGill University, Montreal.
39 Investigating the role of β3 integrin and osteonectin in human melanoma metastasis by Tet-regulated ectopic expression
Gardiner, B.B., Smit, D.J. and Sturm, R.A.
Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
40 Temporally defined and magnitude specific co-orporation of Erk1/2 activation with transforming growth factor-β signaling in epithelial to mesenchymal transition
Wang, B, Steveners, K, Burgess, AW and Zhu, H-J
Ludwig Institute for Cancer Research, Melbourne, Australia
41 Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen.
Hooper, JD*, Zijlstra, A, Aimes, RT, Liang, H, Claassen, GF, Tarin, D, Testa, JE and Quigley, JP
School of Life Sciences, Queensland University of Technology, Brisbane, Australia; The Scripps Research Institute, La Jolla, California, USA *current position: School of Life Sciences, Queensland University of Technology, Brisbane, Australia
42 Ghrelin and a novel Ghrelin isoform have potential autocrine/paracrine roles in hormone-dependent cancer.
Jeffery, P, Herington, AC and Chopin, LK
Hormone-Dependent Cancer Program, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
43 Kallikrein 4 mediates interactions between prostate cancer cells and osteoblasts: a potential role in bone metastasis?
Collard, R, Veveris-Lowe, T, Herington, A and Clements, J
Science Research Centre, Queensland University of Technology, Brisbane, Australia
44 The role of Osteonectin in MDA-MB-231 breast cancer cell tumor growth and metastasis
Koblinski, JE*, Kaplan-Singer, B*, Wu, M*, Wang, S#, Harms, J**, Welch, D^, Engbring, JA* and Kleinman, HK*
CDBRB, NIDCR, NIH, Bethesda, USA; *Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA, #Salivary Gland Disease Center, Beijing Institute of Dental Research, Beijing, China, **Jack Gittlen Cancer Research Institute, The Pennsylvania State University College of Medicine, Hershey, PA, USA, ^Department of Pathology, University of Alabama-Birmingham, Birmingham, AL, USA.
45 A metastasis-promoting laminin-1 peptide up-regulates fibronectin expression in malignant cells.
Engbring, JA, Hossain, R, Koblinski, JE and Kleinman, HK
CDBRB, NIDCR, NIH, Bethesda, USA
46 HScrib is a functional homologue of the Drosophila tumour suppressor Scribble
Dow, LE*, Brumby, AM**, Muratore, RM*, Coombe, ML**, Russell, SM#, Richardson, HE** and Humbert, PO*
Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia; *Cell Cycle and Cancer Genetics Laboratory **Cell Cycle and Development Laboratory #Immune Signaling Laboratory Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, 3002, Victoria, Australia
47 A role for cortactin in coupling cadherin ligation to actin assembly and cell junction biogenesis
Falak Helwani*, Eva Kovacs**, Scott Weed***, Alan Fanning **** and Alpha Yap*
Institute for Molecular Biosciences, University of QLD, Brisbane, Australia; * Institute for Biomedical Sciences ** School of Biomedical Sciences *** Department of Craniofacial Biology, University of Colorado Health Sciences, Denver, CO, USA. ****Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, NC,27599, USA.
48 p120-catenin is essential for E-cadherin signalling to RAC.
Goodwin, MK*, Thoreson, MA**, Reynolds, AB** and Yap, AS*
Institute for Molecular Biosciences, University of Queensland, Brisbane, Australia; * Institute for Molecular Biosciences, University of Queensland, St Lucia, Brisbane, Australia ** Department for Cancer Biology, Vanderbilt University, Nashville, TN, USA
49 Possible role for WASP family proteins in Cadherin directed actin assembly
Ali, RG 1,2, Verma, S 2, Kovacs, EM 3, Miki, H 4 and Yap, AS 1,2
Department of Physiology and Pharmacology and Institute of Molecular Biosciences, University of Queensland, Brisbane, Australia; 1 School of Biomedical Sciences, University of Queensland, Brisbane, Australia 2 Institute of Molecular Biosciences, University of Queensland, Brisbane, Australia 3 Massachusetts Institute of Technology, Boston, USA 4 University of Tokyo, Tokyo, Japan
50 The role of Ena/VASP proteins in Cadherin function
Scott, JA , Gertler, FB* and Yap AS
IMB/Physiology and Pharmacology , University of Queensland, Brisbane, Australia; *Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA
51 Stromal expression of Caveolin-1 regulates breast cancer progression
Anderson, RL, Henderson, M, Waring, P and Sloan, EK
Research Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria, Australia
52 Sox10 expression induces EMT and generation of neural crest
Farlie, PG, McKeown, SJ and Newgreen, DF
Embryology, Murdoch Childrens Research Institute, Melbourne, Australia
53 Tubular transdifferentiation is induced by advanced glycation endproducts (AGE) via a CTGF dependent pathway.
Burns, WC, Thomas, MC, Kantharidis, P, Tikellis, C, Forbes, J and Cooper, ME
Division of Diabetic Complications, Baker Heart Research Institute, Melbourne, Australia; Division of Diabetes Complications, Baker Heart Research Institute, PO Box 6492, Melbourne, VIC, 8008.
54 Regulation of β-catenin subcellular localisation by Rac1-dependent changes in actin
Sharma, M and Henderson, BR
Westmead Millennium Institute, University of Sydney, Sydney, Australia
55 The anti-adhesin podocalyxin is an independent predictor of breast cancer metastasis and its overexpression disrupts breast carcinoma cell junctions
Somasiri, AM *, Nielsen, J **, Makretsov, N ***, Gilks, BC ***, Huntsman, D *** Gelmon, K ***, Kershaw, BD ****, McNagny, KM ** and Roskelley, CD *
* Dept of Anatomy and Cell Biology, University of British Columbia, Vancouver BC, Canada. ** Biomedical Research Center, University of British Columbia, Vancouver BC, Canada. *** Genetic Pathology Evaluation Centre, Vancouver General Hospital, BC Cancer Agency and the University of British Columbia, Vancouver BC, Canada, ****University of Michigan Medical Center, Department of Pediatrics, Ann Arbor, Michigan
56 Matrix metalloproteinase-3 causes genomic instability and epithelial-to-mesenchymal transition through induction of reactive oxygen species
Derek Radisky, Jimmie Fata, Dinah Levy, Zena Werb* and Mina Bissell
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, USA; *Department of Anatomy, University of California, San Francisco
57 The ETS transcription factor Elf5 is a modulator of prolactin action on the mammary epithelium during pregnancy, and is expressed in a number of epithelial breast cancer cell lines.
Harris, J*, Naylor, MJ*, Robertson, FG*, Blazek, K*, Lindeman, GJ^, Visvader, J^ and Ormandy, CJ*
Cancer Research Program, Garvan Institute, Sydney, Australia; *Garvan Institute of Medical Research, St Vincent’s Hospital Darlinghurst NSW 2010 Australia, ^The Walter and Eliza Hall Institute of Medical Research Bone Marrow Research Laboratories, PO Royal Melbourne Hospital, VIC 3050 Australia
58 Signals involved regulating EMT by the MET receptor tyrosine kinase; a role for the CRK adapter protein
Louie Lamorte, Sonia Rodrigues, Gabriel Chan, Monica Naujokas and Morag Park
Biochemistry, McGill University, Molecular Oncology group (H5-10), Montreal, Canada; Molecular Oncology Group, Departments of Medicine, Oncology, and Biochemistry, McGill University Health Centre, 687 Pine Ave. West, Montreal, Quebec H3A 1A1 CANADA
59 Implication of the MAGI-1/PTEN signalosome in stabilization of adherens junctions and suppression of invasivesess
Kotelevets, L, *van Hengel, J, **Bryuneel, E, Kruglov, A, **Mareel, M, *van Roy, F and Chastre, E
U410, INSERM, Paris, France; *Department for Molecular Biomedical Research, VIB-Ghent University, B-9052 Ghent **Laboratory of Experimental Cancerology, Ghent University Hospital, B-9000 Ghent, Belgium.
60 Expression of the Slug transcription factor in tissues of adult mice
Parent, AE, Choi, C, Gridley, T* and Kusewitt, DF
Veterinary Biosciences, The Ohio State University, Columbus, United States; Jackson Laboratory Bar Harbor, ME USA
61 Protein interactions of E-cadherin during trafficking in epithelial and cancer cells
S.R. Joseph, K.C. Miranda, A.S. Yap, R.D. Teasdale and J.L. Stow
Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
62 TGFβ induces EMT indicated by reduced E-Cadherin
Nguyen-tat, M, Adler, G and Menke, A
Internal Medicine I, University of Ulm, Ulm, Germany