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Record of the 5th International EMT Meeting

Monday October 10 - Thursday October 13, 2011 www

Convenors: Jean-Paul Thiery and Erik (Rik) Thompson

Hosted by The Institute of Molecular and Cell Biology, Singapore

Conference Flyer: jpg file


  • TEMTIA: Betty Hay Award
  • TEMTIA Poster Award and Travel Bursaries
  • AAA (American Association of Anatomists): Travel Bursaries




Epithelial-Mesenchymal Transition (EMT) is a cellular process where cells in an epithelium acquire the ability to invade the underlying extracellular matrix or adjacent tissue. It is a normal process in development used for the formation of three-dimensional structure in the embryo but is usually associated with pathologies in the adult.

This meeting is designed to bring together Developmental Biologists, Cancer Biologists and Pathologists, who might not normally interact in discipline-specific meetings, to discuss the common and disparate elements of EMT in their research. We expect that results presented in the areas of cancer metastasis, organ fibrosis, wound healing and embryonic development will lead to new insights and approaches that will move each of the respective research fields and advance health research.

Platform talks will be given by a combination of senior investigators in the field and newer investigators selected from submitted abstracts. Substantial poster presentation time will enable each participant to share their work with the other attendees.


12.00pm - 12.45pm   Registration
12.45pm - 1.00pm   Welcome address
Jean Paul Thiery, Convenor of TEMTIA-V
Institute of Molecular and Cell Biology, A*STAR, Singapore
   Session 1: Cell/Molecular Biology of EMT
Chairperson: Erik W. Thompson
St. Vincent's Institute, University of Melbourne, Australia.
1.00pm - 1.30pm   Shigeo Ohno, Yokohama City University, Japan
Epithelial cell polarity and the Par-aPKC complex
1.30pm - 2.00pm   Russ P. Carstens, University of Pennsylvania, USA
Defining the complex role of alternative splicing in the EMT
2.00pm - 2.30pm   Yeesim Khew-Goodall, Centre for Cancer Biology, SA Pathology, Australia
The miR-200 family of microRNAs in EMT
2.30pm - 2.50pm   Michael J. Murray, The University of Melbourne, Australia
Short talk: Identification of new EMT factors in the fly: an RNAi screen using Wing Eversion
2.50pm - 3.10pm   Carole LaBonne, Northwestern University, USA
Short talk: Coordinate regulation core EMT regulatory factors
3.10pm - 3.40pm   Afternoon Teabreak
   Session 2: Cell/Molecular Biology of EMT
Chairperson: David M. Epstein
OSI Pharmaceuticals, USA
3.40pm - 4.10pm   Hongquan Zhang, Peking University Health Science Center, China
Role of an integrin-interacting protein in the regulation of EMT in cancer and fibrosis
4.10pm - 4.40pm   Masatoshi Takeichi, Center for Developmental Biology, RIKEN Kobe, Japan
Adherens Junction Remodeling for Epithelial Migration and Closure
4.40pm - 5.10pm   Senthil K. Muthuswamy, University of Toronto, Canada
Short talk: Loss of cell polarity gene Par3 and metastasis
5.10pm - 5.30pm   Eric Theveneau, University College London, United Kingdom
Short talk: Lipid signalling links EMT and in vivo collective invasion via turnover of the cell-cell adhesion complex
5.30pm - 5.50pm   Jianmin Zhang, Roswell Park Cancer Institute, USA
Short talk: Pulsed expression of SNAI-1 implicates epigenetic silencing in epithelial-to-mesenchymal transition
   The EMBO Lecture & Betty Hay Oration
Chairperson: Jean Paul Thiery
Institute of Molecular and Cell Biology, A*STAR, Singapore
5.50pm - 6.50pm   Betty Hay Reception
6.50pm - 7.50pm   M. Angela Nieto, Instituto de Neurociencias (CSIC-UMH), Spain
The ins and outs of the EMT in health and disease
7.50pm - 9.20pm   Dinner & Poster session


7.30am - 8.30am   Breakfast & dialogue session
   Session 3: Developmental EMT
Chairperson: Raymond Runyan
University of Arizona, USA
8.30am - 9.00am   Roberto Mayor, University College London, United Kingdom
Collective cell migration and EMT in the neural crest cells
9.00am - 9.30am   Shinichi Aizawa, Center for Developmental Biology, RIKEN Kobe, Japan
Post-transcriptional Regulation of Cadherin and Integrin by EPB41L5 in Epithelial-Mesenchymal Transition
9.30am - 9.50am   Ali Nawshad, The University of Nebraska Medical Center, USA
Short talk: TGFβ induced cell cycle arrest is the prerequisite for EMT in palate development
9.50am - 10.10am   Paul M. Kulesa, Stowers Institute for Medical Research, USA
Short talk: The Developmental Program of the Neural Crest Influences Malignant Melanoma to Drive Plasticity and Invasion
10.10am - 10.30am   Alpha Yap, Institute for Molecular Bioscience, Australia
Short talk: Dysregulation of the junctional actin cytoskeleton by HGF: a novel mechanism that acutely disrupts the epithelial zonula adherens
10.30am - 11.00am   Morning Teabreak
11.00am - 11.40am   Jenny Chang, Methodist Cancer Center, USA
Therapeutic Resistance of Tumour-initating Cells in Breast Cancer
   Session 4: Developmental EMT
Chairperson: Guojun Sheng
Center for Developmental Biology, RIKEN Kobe, Japan
11.40am - 12.10pm   José Luis de la Pompa, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain
Notch signaling in cardiac valve formation and disease
12.10pm - 12.40pm   David McClay, Duke University, USA
The gene regulatory network controlling EMT in sea urchin embryos
12.40pm - 1.00pm   Kathy K.H. Svoboda, Texas A&M Health Science Center, USA
Short talk: Ephrin reverse signaling promotes palate fusion through a PI3 Kinase dependent mechanism
1.00pm - 1.20pm   Yukiko Nakaya, Center for Developmental Biology, RIKEN Kobe, Japan
Short talk: CLASP-mediated microtubule anchoring promotes the cell-basement membrane interaction through dystroglycan in gastrulation EMT
1.20pm - 1.40pm   Kyra Campbell, Institute of Research in Biomedicine Barcelona, Spain
Short talk: Specific GATA factors act as conserved inducers of an epithelial-to-mesenchymal transition
1.40pm - 2.20pm   TEMTIA Annual General Meeting (TEMTIA Members only)
1.40pm - 3.30pm   Lunch & Poster session
Afternoon interaction and independent dinner


7.30am - 8.30am   Breakfast & dialogue session
   Session 5: Mathematical Modeling of EMT and Invasion
Chairperson: Donald Newgreen
The Murdoch Childrens Research Institute, Australia
8.30am - 9.00am   Dawn Walker, University of Sheffield, United Kingdom
Computational Modelling of Cellular Communities – the effect of “Antisocial Cells”
9.00am - 9.30am   Muhammad H. Zaman, Boston University, USA
Multi-scale computation of EMT and collective cell motion in complex environments
9.30am - 9.50am   Ian Overton, MRC Human Genetics Unit Western General Hospital, United Kingdom
Short talk: Machine Learning Functional Networks to Infer EMT Genes
9.50am - 10.10am   Véronique Delmas, Institut Curie, France
Short talk: Biological and mathematical modeling : melanoblast proliferation and dermal to epidermal migration.
10.10am - 10.30am   J. Guy Lyons, University of Sydney, Australia
Short talk: A mathematical model to simulate cooperation between carcinoma cells that have undergone an EMT and those that remain well differentiated
10.30am - 11.00am   Morning Teabreak
   Session 6: Organ Fibrosis
Chairperson: Raghu Kalluri
Beth Israel Deaconess Medical Center, USA
11.00am - 11.30am   Valerie LeBleu, Harvard Medical School/Beth Israel Deaconess Medical Center, USA
The origin of myofibroblasts and the contribution of EMT in fibrosis
11.30am - 12.00pm   Zea Borok, University of Southern California, USA
EMT in pulmonary fibrosis: fact or fiction?
12.00pm - 12.20pm   Simon J. Conway, Indiana University School of Medicine, USA
Short talk: Lineage mapping cardiac fibroblasts during both normal homeostatic and pathological transformed states
12.20pm - 12.40pm   Raffaele Strippoli, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain
Short talk: Inhibition of transforming growth factor-activated kinase-1 (TAK-1) blocks and reverses epithelial to mesenchymal transition of mesothelial cells
12.40pm - 1.00pm   Yue-Lei Chen, Chinese Academy of Sciences (CAS), China
Short talk: Sorafenib Inhibits Transforming Growth Factor β1-Mediated Epithelial-Mesenchymal Transition and Apoptosis in Mouse Hepatocytes
1.00pm - 2.30pm   Lunch & Poster Session
   Session 7: Stem Cells and EMT
Chairperson: Pierre Savagner
Institut de Recherche en Cancérologie de Montpellier, France
2.30am - 3.00pm   Alain Puisieux, Centre de Recherche de Cancrologie de Lyon, France
Commitment to an EMT program catalyzes oncogene-induced cell transformation and initiates tumor initiation
3.00pm - 3.30pm   Gary L. Johnson, University of North Carolina, USA
Histone H2A/H2B Acetylation Regulated by MAP3K4 and CBP Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells
3.30pm - 4.00pm   Thomas Brabletz, University of Freiburg, Germany
MicroRNAs, EMT and Cancer Stem Cells
4.00pm - 4.20pm   Aristidis Moustakas, Uppsala University, Sweden
Short talk: Regulation of cancer stem cell potential by the EMT inducers HMGA2 and Snail1
4.20pm - 4.40pm   Abdelkader SELMI, Institut de Recherche en Cancérologie de Montpellier, France
Short talk: Slug regulates stem/progenitor cell dynamics during mammary gland morphogenesis
4.40pm - 6.30pm   Afternoon Teabreak & Poster session
6.30pm   Depart to Banquet Venue (Transport is provided from conference venue)
7.00pm - 10.00pm   TEMTIA-V Banquet


   Session 8: Cancer and EMT
Chairperson: Hongquan Zhang
Peking University Health Science Center, China
8.30am - 9.00am   Owen Sansom, The Beatson Institute for Cancer Research, United Kingdom
Loss of p53 permits the development of invasive adenocarcinoma following Apc loss
9.00am - 9.30am   Raghu Kalluri, Beth Israel Deaconess Medical Center, USA
Pericyte Depletion Results in Hypoxia Associated Epithelial to Mesenchymal Transition and Metastasis Mediated by Met Signalling Pathway
9.30am - 9.50am   Yibin Kang, Princeton University, USA
Short talk: miR-200s enforces MET and influences Sec23a-dependent cancer cell secretome to promote metastatic colonization
9.50am - 10.10am   Sarah M. Dunlap, The University of Texas, USA
Short talk: Obesity Promotes Epithelial-To-Mesenchymal Transition and Tumor Progression in a Syngeneic Mouse Model of Claudin-Low Breast Cancer
10.10am - 10.30am   Kern Rei Chng, Genome Institute of Singapore, A*STAR, Singapore
Short talk: ERG, HDACs and EZH2 promote Epithelial Mesenchymal Transition in Prostate Cancers through Harmonizing AR Transcriptional Output
10.30am - 11.00am   Morning Teabreak
11.00am - 11.40am   Yoshiaki Ito, Cancer Science Institute of Singapore, NUS, Singapore
Runx3 protects gastric epithelial cells against EMT
   Session 9: : Cancer and EMT
Chairperson: Elizabeth Williams
Monash University, Australia
11.40am - 12.10pm   Klaus Pantel, University Medical Center Hamburg-Eppendorf, Germany
Micrometastases, circulating tumour cells and cancer dormancy
12.10pm - 12.30pm   Jihe Zhao, University of Central Florida, USA
Short talk: KLF8 Regulation of EMT and Breast Cancer Metastasis
12.30pm - 12.50pm   David I. Bellovin, Stanford University, USA
Short talk: A Transgenic Model of Twist1-Induced Metastasis is Associated with a Gene Signature that is Prognostic in Patients with Hepatocellular Carcinoma
12.50pm - 1.10pm   Ruby Yun-Ju Huang, Cancer Science Institute of Singapore, NUS, Singapore
Short talk: Epithelial-mesenchymal gene expression signature defines clinically relevant subtypes in epithelial ovarian cancer
1.10pm - 1.30pm   Geert Berx, Ghent University, Belgium
Short talk: Role of EMT-inducing Transcription Factors in Epithelial Cancer Progression
1.30pm - 3.00pm   Lunch & Poster Session
   Session 10 : Drug Discovery and EMT
Chairperson: M. Angela Nieto
Instituto de Neurociencias (CSIC-UMH), Spain
3.00pm - 3.30pm   David M. Epstein, OSI Pharmaceuticals, USA
Epithelial-mesenchymal transition in context of cancer therapy
3.30pm - 4.00pm   Patrick Humbert, Peter MacCallum Cancer Centre, Australia
Targeting Cell polarity and RAS/MAPK signalling in EMT and Epithelial tumour progression
4.00pm - 4.40pm   Sir David Lane, p53 Laboratory, A*STAR, Singapore
New antibodies to cMet
4.40pm - 5.00pm   Closing remarks & Award presentation ceremony
Erik W. Thompson, Co-convenor of TEMTIA-V
St. Vincent’s Institute, University of Melbourne, Australia


6th TEMTIA Meeting,
13-16 November, 2013, Alicante, Spain



Special issues of CELLS TISSUES ORGANS:

The journal devotes special issues to papers of the EMT conferences:
"Epithelial-Mesenchymal Transitions: New Advances in Development, Fibrosis and Cancer" 4th International EMT Meeting, Tucson, Ariz., September 2009

"Advances in Epithelial-Mesenchymal Transitions" (Vol. 185, No. 1-3, 2007). A multidisciplinary overview of the EMT process in development and disease based on the 2nd International EMT Meeting, Vancouver, October 2005.

"Recent Progress in Epithelial-Mesenchymal Transitions" (Vol 179, No. 1-2, 2005). Selected reviews and new data from the International EMT Meeting, in Port Douglas, October 2003

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