4thEMT Meeting ~ Scientific Program
Meeting held in Westward Look Resort, Tucson, Arizona
Wednesday September 23-Saturday September 26, 2009
Convenors: Ray Runyan and Parker Antin
Conference Flyer: PDF file (540kb)
Epithelial-Mesenchymal Transition (EMT) is a cellular process where cells in an epithelium acquire the ability to invade the underlying extracellular matrix or adjacent tissue. It is a normal process in development used for the formation of three-dimensional structure in the embryo but is usually associated with pathologies in the adult.
This meeting is designed to bring together Developmental Biologists, Cancer Biologists and Pathologists, who might not normally interact in discipline-specific meetings, to discuss the common and disparate elements of EMT in their research. We expect that results presented in the areas of cancer metastasis, organ fibrosis, wound healing and embryonic development will lead to new insights and approaches that will move each of the respective research fields and advance health research.
Platform talks will be given by a combination of senior investigators in the field and newer investigators selected from submitted abstracts. Substantial poster presentation time each morning will enable each participant to share their work with the other attendees.
| 3:00 - 6:00 | Session 1 | Overview and sampling of EMT systems Parker Antin (Tucson)- Welcome Ray Runyan (Tucson)- EMT in developing heart valves: Still useful after all these years Hal Chapman (San Francisco)-Integrin Dependent Cross-talk between β-catenin and Smad Signaling Regulates EMT Wiliam Schiemann (Denver)- Activated Abl Kinase Inhibits Oncogenic Transforming Growth Factor-β Signaling, EMT, and Tumorigenesis in Mammary Tumors |
| 8:00-10:00 | Opening Reception |
Thursday, Sept. 24
| 7:30-9:25 | Breakfast and Poster Session 1 | |
| 9:25-10:35 | Session 2 | Physiological EMT: Development Guojun Sheng (Kobe)- Gastrulation EMT in chick embryos Nicole Vincent-Jordan (Chapel Hill)- MEKK4-dependent epigenetic regulation of developmental EMT in trophoblast stem cells |
| 10:55-12:40 | Session 3 | Development II Michelle Talquist (Dallas)-Deletion of Neurofibromatosis I in the epicardium leads to premature epithelial to mesenchymal transition Joey Barnett (Nashville)- BMP-2 and TGFβ2 Shared Pathways Regulate Endocardial Cell EMT Andrea Ladd (Cleveland)- Muscleblind-like 1 is a negative regulator of TGFβ-dependent epithelial-mesenchymal transition of atrioventricular canal endocardial cells |
| 1:40-3:25 | Session 4 | Physiological EMT: Palate EMT? Kathy Svoboda (Dallas)-Palate Fusion is Twist and Snail Dependent Downstream of Tgfbeta3 and PI3 kinase Ali Nawshad (Lincoln)- Splice variants of ALK5 regulate medial palatal seam cell morphogenesis Yukiko Kitase (Vancouver)- The Role of Periostin during Palatal Development |
| 3:45-5:30 | Session 5 | Pathological EMT: Fibrosis Andras Kapus (Toronto)- Fate-determining mechanisms in epithelial-myofibroblast transition: Smad3 is a critical inhibitor and timer of the myogenic program in the epithelium Xueming Qian (Thousand Oaks)- Context-Dependent Wnt Modulator WISE Regulates Myofibroblast Formation and Activation in a Mouse Model of Bleomycin-induced Lung Fibrosis Beiyun Zhou (Los Angeles)- Interactions between Transforming Growth Factor-β1 (TGF-β1)/Smad3 and Wnt Signaling Pathways Regulate EMT and α-Smooth Muscle Actin Expression in Alveolar Epithelial Cells (AEC) |
| 5:30-6:30 | TEMTIA business Meeting | |
Friday, Sept. 25
| 7:30-9:25 | Breakfast and Poster Session 2 | |
| 9:25-10:35 | Session 6 | Pathological EMT: Metastasis I Shoukat Dedhar (Vancouver)- Role of EMT in Breast and Prostate Cancer Progression Alexandre Deshiere (Grenoble)- Involvement of Protein Kinase CK2 in SNAI1-mediated Epithelial-to-Mesenchymal Transition |
| 10:55-12:40 | Session 7 | Pathological EMT: Metastasis II Pierre Savagner (Montpelier)- Role of Slug in supporting partial EMT phenotype during mammary growth and breast carcinoma progression Guo-fu Hu (Boston)-Cooperativity between EMT and non-EMT cells in spontaneous metastasis of oral squamous carcinoma cells Gretchen Argast (Farmingdale)-Recapitulation of EMT in vitro and in vivo with multiple drivers in H358 non-small cell lung cancer cells |
| 1:40-3:25 | Session 8 | Pathological EMT: Metastasis III Aristidis Moustakas (Uppsala) - Epithelial-mesenchymal transition under the control of TGF-β signaling Jing Yang (San Diego)- Regulation of Tumor Invasion by Twist Samy Lamouille (San Francisco)-Role of mTOR signaling in TGF-β-induced EMT |
| 6:00-7:00 | Session 9 | Neural Crest and EMT ~ Betty Hay Memorial Lecture Marianne Bronner-Fraser (Los Angeles)- Gene regulatory interactions mediating neural crest formation and onset of migration |
| 7:00-9:00 | Betty Hay Reception and Buffet | |
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Saturday, Sept. 26
| 7:30-9:25 | Breakfast and Poster Session 3 | |
| 9:25-10:35 | Session 10 | Physiological and Pathological EMT: Transcriptional Regulation I Angela Nieto (Alicante)- An ancestral function for the Snail/Scratch genes in the control of cell proliferation/differentiation Antonio Garcia de Herreros (Barcelona)- Regulation of Snail1 expression during EMT |
| 10:55-12:40 | Session 11 | Transcription II Russ Carstens (Philadelphia)- Epithelial splicing regulatory proteins (ESRPs) enforce an extensive splicing regulatory program that is lost during the epithelial to mesenchymal transition (EMT) Irina Shapiro (Boston)- A transcriptome-wide analysis of gene expression and alternative splicing during EMT Micheal Henry (Iowa City)-Zeb1 regulates transendothelial migration of prostate cancer cells |
| 1:40-3:25 | Session 12 | Post transcriptional regulation of EMT Yeesim Khew-Goodall (Adelaide)- The Pez-TGFb-miR200-ZEB1/2 pathway in epithelial-mesenchymal transition Jacqueline Banyard (Boston)- MicroRNA control of MET (mesenchymal-epithelial transition) in a new tumor METastasis model Jennifer Richer (Denver)- Loss of microRNA-200c, a marker of EMT, Aggressiveness and Chemoresistance in Female Reproductive Cancers |
| 3:45-5:30 | Session 13 | Directions and issues in EMT research Beatrice Knudsen (Seattle)-Is Mesenchymal-to-Epithelial Transition (MET) the Bottleneck of Prostate Cancer Progression in the Bone Marrow? Stéphane Ansieau (Lyon)- Intimate crosstalk between failsafe program escape and EMT Rik Thompson (Melbourne)- Epithelial-Mesenchymal Plasticity Programs Implicit in Breast Cancer Cell Lines: Insights into Breast Cancer Metastasis |
| 6:00- 9:00 | Conference Dinner w/ Music ~ Conference close | |