3rdEMT Meeting ~ Scientific Program
Epithelial-Mesenchymal
Transition
10-12 September, 2007, Larischa Palace, Cracow, Poland
As an EMBO Workshop, co-organized by TEMTIA and Marie-Curie Epiplastcarcinoma RTN network
Conference Poster: PDF
Conference website: EMBO Workshops
| Pierre Savagner | Aristides Moustakis |
| Antonio Garcia de Herreros | Amparo Cano |
International Scientific Committee:
| Shoukat Dedhar Canada | Raymond Runyan USA |
| Raghu Kalluri USA | Jean-Paul Thiery Singapore |
| Suresh Mohla USA | Kristin Verschueren Belgium |
| Donald Newgreen Australia | Robert Weinberg USA |
| Angela Nieto Spain |
The Poster abstracts may be accessed here...
| 8:00 AM | Registration | |
| 8:30 AM - 10:30 AM |
Session I | EMT and Development (I) Chair: Raghu Kalluri Larischa Palace, Conference Room THE INAUGURAL ELIZABETH HAY LECTURE: Mechanochemistry of cell adhesion in epithelial cell plasticity Thiery, JP*, Dufour, S#, Chu, HS*, Pincet, F§, Eder, O#, Thomas, W#, Martinez-Rico, C# and Nassoy, P+ *Systems Biology , Institute of Molecular and Cell Biology, 61 Biopolis Drive (Proteos), Singapore, Singapore 138673, Singapore; #CNRS Institut Curie Paris; § Ecole Normale Superieure Paris EMT-related and EMT-independent regulation of cell adhesion and movement by Snail Nieto, MA Instituto de Neurociencias de Alicante, CSIC-UMH Apartado 18. San Juan de Alicante. Spain. The polarity regulators Scribble and DLG control epithelial migration during development, wound healing and tumourigenesis Lukas E. Dow*, Jeffrey S. Kauffman*, Ryan Galea*, Jacinta Caddy^, Stephen M. Jane^, Sarah M. Russell# and Patrick O. Humbert* *Cell Cycle & Cancer Genetics Laboratory, #Immune Signalling Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia. ^Rotary Bone Marrow Research Laboratories, Parkville, Australia. |
| 11:00 AM - 12:30 PM |
Session II | EMT and Development (II) Chair: Raghu Kalluri Larischa Palace, Conference Room Gene regulatory network states that control EMT. McClay, D Developmental Biology, Duke University, Box 90338, Durham, NC 27708, USA; Conserved and novel features of the NFkB-Slug-Twist network involved in Xenopus mesoderm formation and EMT Klymkowsky, M Molecular, Cellular & Developmental Biology, University of Colorado, Boulder, 347 UCB, Boulder, CO 80309-0347, USA Photoactivatable GFP resolves drosophila mesoderm migration behaviour Murray, MJ and Saint, R Centre for the Molecular Genetics of Development, Research School of Biological Sciences, The Australian National University, Building 46, Acton, Canberra, ACT 0200, Australia |
| 12:30 PM - 2:00 PM | Lunch and Poster viewing Wierzynek Restaurant and Conference Foyer Posters here... |
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| 2:00 PM - 3:50 PM |
Session III | Cell signalling and EMT (I) Chair: Angela Nieto Larischa Palace, Conference Room Smad proteins of the TGF β pathway instruct a network of transcription factors for the establishment of EMT Moustakas, A, Thuault, S, Vanlandewijck, M, Tan, E-J, Raja, E and Heldin, C-H Ludwig Institute for Cancer Research, Box 595, BioMedical Center, Uppsala University, Uppsala SE-751 24, Sweden. Searching for novel regulators of EMT Wu, MY, Daly, A and Hill, CS Developmental Signalling Laboratory, London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK PDGF Links TGF-β Signaling to Nuclear β-Catenin Accumulation in Hepatocellular Carcinoma Progression Fischer, ANM, Fuchs, E, Mikula, M, Huber, W, *Beug, H and Mikulits, W Department of Medicine I, Division: Institute of Cancer Research, Medical University of Vienna, Borschke-Gasse 8A, Vienna, 1090, Austria; Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria 3:30 PM 71 The Transcription Factor Snail Represses Crumbs3 Expression and Disrupts Apico-Basal Polarity Complexes Whiteman, EL, Liu, Chia-Jen, Fearon, ER and Margolis, B Internal Medicine, University of Michigan, 109 Zina Pitcher Place, 1698 Biomedical Science Research Building, Ann Arbor, MI 48105, USA |
| 3:50 PM | Afternoon Tea Conference Room Foyer, Larischa Palace | |
| 4:30 PM - 6:00 PM |
Session IV | Cell signalling and EMT (II): Chair: Angela Nieto Larischa Palace, Conference Room The Par/Tiam1 polarity complex controls epithelial and mesenchymal properties of epithelial cells. Collard, J Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, 1066 CX, The Netherlands Regulation of EMT and Wnt signaling by Integrin-Linked Kinase Dedhar, S Biochemistry and Molecular Biology, University of British Columbia/BC Cancer Research Centre, Vancouver, BC V5Z1L3, Canada EMT and Oncogenic Signaling by TGF-β in Mammary Epithelial Cells Schiemann, WP Department of Pharmacology, MS8303, University of Colorado Health Sciences Center, Aurora, CO 80045, USA |
| 6:00 PM | POSTERS / EpiPlast Carcinoma AGM | |
| 7:00 PM | Welcome Reception Main Hall, Larischa Palace | |
| 8:30 AM - 10:00 AM |
Session V | EMT and Cancer (I) Chair: Antonio Garcia de Herreros Larischa Palace, Conference Room Invasive growth: a MET-driven genetic programme for cancer and stem cells Comoglio, P IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Torino, 10060, Italy EMT in the neural crest model: Does functional manipulation of adhesion and cytoskeletal systems reset the sensitivity to pro-EMT growth factors? Don Newgreen1, Dong Zhang1, Honor Hugo1, Peter Farlie2, Sonja McKeown1 1Embryology Laboratory, and 2 Craniofacial Sciences Laboratory, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Parkville, 3052, Australia. The microRNA-200 family regulates the E-cadherin repressors, ZEB1/deltaEF-1 and SIP1/ZEB2 and EMT Philip A Gregory, Andrew G Bert, Emily L Paterson, Anna Tsykin, Mathew A Vadas, Yeesim Khew-Goodall and Gregory J Goodall Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia, 5000 |
| 10:30 AM - 11:30 AM | Debate: | EMT-MET Cycles in tumours Larischa Palace, Conference Room Amparo Cano, Gerhard Christofori, Pierre Savagner and Erik (Rik) Thompson |
| 11:30 AM - 12:40 PM | Session VI | EMT and Cancer (II) Chair: Antonio Garcia de Herreros Larischa Palace, Conference Room Distinct mechanisms of tumor invasion and metastasis Lehembre, F, Wicki, A, Yilmaz, M, Grotegut, S, Kren, A, Fantozzi, A, Achermann, C and Christofori, G Institute of Biochemistry and Genetics, University of Basel, CH - 4058, Switzerland Gene signatures defining Epithelial Mesenchymal Transition and stem cell lineage are a defining characteristic of human breast cancer subtypes Blick, T#, Widodo, E. ^,§, Waltham, M#,^, Hugo, H*, Newgreen, DF*, Lenburg, ME## and Thompson, EW#,^ #St. Vincent’s Institute and ^University of Melbourne Dept. of Surgery, St. Vincent’s Hospital, Australia; § Faculty of Medicine, Brawijaya University, East Java, Indonesia; *Embryology Laboratory, Murdoch Children’s Research Institute, Parkville, Australia; ##Department of Genetics and Genomics, Boston University School of Medicine, Boston, MA 02118, USA; **Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA |
| 12:40 PM - 2:15 PM | Lunch/ and Poster viewing Wierzynek Restaurant and Conference Foyer | |
| 2:15 PM - 3:45 PM |
Session VII | EMT and Cancer (II) Chair: John Collard Larischa Palace, Conference Room Understanding the role of Snail factors and other EMT regulators in tumour progression Cano, A Biochemistry, Universidad Autonoma de Madrid, Instituto de Investigaciones Biomedicas "Alberto Sols" CSIC-UAM, Madrid,, Spain Malignant progression in colorectal cancer: EMT, β-Catenin & cancer stem cells Brabletz, T Molecular Oncology, Surgery, Univ. of Freiburg, Germany The transcription factor ZEB1 promotes tumor progression by repressing master regulators of epithelial differentiation Aigner, A, Descovich, L, Sultan, A, Brabletz, T* and Foisner, R and Eger, A Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, Austria;*Department of Visceral and General Surgery, Albert-Ludwigs-University, Freiburg, Germany |
| 4:15 PM - 6:05 PM |
Session VIII | EMT and Cancer (II) Chair: John Collard Larischa Palace, Conference Room Cell motility at the invasive front of tumors: The role of novel Wnt/β-catenin target genes Ben-Ze'ev, A Molecular Cell Biology, Weizmann Institute of Science, Hertzl Street, Rehovot, 76100, ISRAEL PDGF-dependent cancer fibroblasts and pericytes as novel cancer drug targets Östman, A Molecular Oncology and Cancer Therapies, Karolinska Institute, Department of Oncology, Stokholm, Sweden β-Arrestin-1 as messenger of endothelin A receptor-driven β-catenin signaling pathway and epithelial to mesenchymal transition: implication for an effective combined therapy in ovarian cancer * Rosano', Laura, * Cianfrocca, Roberta, * Masi, Stefano, * Spinella, Francesca, * Di Castro, Valeriana, *** Nicotra, Maria Rita, ** Natali, Pier Giorgio and * Bagnato, Anna *Laboratories of Molecular Pathology and Ultrastructure, and **Immunology, Regina Elena Cancer Institute, Rome, Italy;***Molecular Biology and Pathology Institute, National Research Council, Rome, Italy. LOXL2 as a player in epidermal homeostasis and early marker of squamous cell carcinomas Peinado, H., Moreno-Bueno, G, Santos, V., Perez-Gomez, E., Hardisson, D.*; De Diego J.I.*, Quintanilla, M., Portillo, F. and Cano, A. Departamento de Bioquimica. Instituto de Investigaciones Biomedicas Alberto Sols Consejo Superior de Investigaciones Cientificas-Universidad Autonoma de Madrid, Spain. *Hospital Universitario de la Paz. 28029 Madrid. Spain |
| 6:05 PM | POSTERS / TEMTIA AGM | |
| 7:00 PM | Conference Dinner Folwark Zalesie | |
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| 8:30 AM - 10:00 AM |
Session IX |
Physiological aspects of EMT Chair: Aristidis Moustakas Larischa Palace, Conference Room The Effects of BMP-7 on EndMT and Cardiac Fibrosis Kalluri, R Center for Matrix Biology, Beth Israel Hospital/Harvard Medical School, Boston, MA 2215, USA Slug regulates early epithelial differentiation by maintaining a metastable phenotype Savagner, P U868 INSERM Centre de Recherche en Cancerologie, CRLC Val d'Aurelle-Paul Lamarque, Montpellier, 34298, France Gene Regulation Network Analysis Suggests Epigenetic Mechanism for Silencing of TIMP3 in EMT Zavadil, J*, Dickman, K#, Bitzer, Mß, Jelinek, J‚^, Grollman, AP# and Blumenberg, M** *Pathology & **Dermatology, NYU School of Medicine, New York, NY; #Pharmacology, SUNY at Stony Brook, NY; ßMedicine, Albert Einstein College of Medicine, Bronx, NY.; ^Leukemia Department, M.D. Anderson Cancer Center, Houston, TX. |
| 10:30 AM - 11:30 AM |
Debate: | EMT in development and physiology Michael Klymkowsky, Raghu Kalluri and Angela Nieto Larischa Palace, Conference Room |
| 11:30 AM - 12:45 PM |
Session X | Physiological aspects of EMT Chair: Aristidis Moustaka Larischa Palace, Conference Room Regulation of EMT in the atrioventricular canal of the developing heart |
| 12:45 PM - 2:15 PM | Lunch and Poster Viewing Conference Room Foyer, Larischa Palace |
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| 2:15 PM - 4:00 PM |
Session XI | Cell signalling and EMT (II) Chair: Paolo Comoglio Larischa Palace, Conference Room The role of IGF/AKT pathways in the induction of epithelium mesenchyme transition |
| 4:00 PM | Close and Announcement of 2009 Meeting | |